The patient is a 77 year old woman who presented in late Jan with severe anemia. In Feb she was diagnosed with myelodysplastic syndrome with no evidence of transformation to acute myelogenous leukemia. She went through 5 rounds of chemotherapy with Vidaza azacytidine over the course of 9 months, with no significant response. She received one unit of RBCs with her 4 th round of chemo and was given Aranesp darbepoetin alfa injections for anemia support. Aranesp is a man-made erythropoiesis stimulating protein which can be used to treat symptomatic anemia associated with myelodysplastic syndromes MDS. After the 5th cycle of chemo, because of the lack of response, Vidaza was discontinued.
Case Study : Acute Myeloid Leukemia
Acute Myeloid Leukemia (AML) | CancerIndex
A year-old female presented to the emergency department with severe headaches, dyspnea on exertion, and petechiae on the lower extremities. A bone marrow biopsy was performed and showed 90 percent lymphoid blasts. Metaphase cytogenetics showed a normal female karyotype. FISH for bcr-abl was positive.
New CAR T case study shows promise in acute myeloid leukemia
Objective: The aim of the current study was to assess the relation between occupational exposure to solvents and the risk of acute myeloid leukemia AML. Methods: Altogether, this study comprises 15 incident cases of AML diagnosed in Finland, Norway, Sweden and Iceland from and 76 controls matched by year of birth, sex, and country. Occupational records were linked with Nordic Occupational Cancer Study job exposure matrix JEM to estimate quantitative values for 26 occupational exposure factors. Results: We did not observe statistically significantly increased risk for exposure to any of the solvents. HR estimates for high levels of toluene HR 1.
A year-old woman presents to the emergency department following two weeks of progressive dyspnea and fatigue, and a new rash. Her medical history is significant for stage 2 chronic kidney disease, coronary artery disease, and diabetes. Physical examination results are within normal limits, except for skin pallor and a petechial rash on the lower extremities bilaterally.