The ketogenic diet KD is used to treat refractory epilepsy, but the mechanisms underlying its neuroprotective effects remain unclear. Here, we show that the gut microbiota is altered by the KD and required for protection against acute electrically induced seizures and spontaneous tonic-clonic seizures in two mouse models. Mice treated with antibiotics or reared germ free are resistant to KD-mediated seizure protection. Enrichment of, and gnotobiotic co-colonization with, KD-associated Akkermansia and Parabacteroides restores seizure protection.
Essays on Animal Rights
Ethical and Scientific Considerations Regarding Animal Testing and Research
Essays on Animal Cruelty
Research is showing benefits for everything from depression to liver disease. Is it just the caffeine? Remember when people and their doctors used to worry that coffee would harm their hearts, give them ulcers, and make them overly nervous?